APBA3
Domain
Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
Function
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
Tissue Specificity
Expressed in all tissues examined with lower levels in brain and testis.
Cellular localization
- Cytoplasm
- Perinuclear region
Alternative names
MINT3, X11L2, APBA3, Amyloid-beta A4 precursor protein-binding family A member 3, Adapter protein X11gamma, Neuron-specific X11L2 protein, Neuronal Munc18-1-interacting protein 3, Mint-3