APCS
Function
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
Involvement in disease
SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
Post-translational modifications
N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148).
Sequence Similarities
Belongs to the pentraxin family.
Tissue Specificity
Found in serum and urine.
Cellular localization
- Secreted
Alternative names
PTX2, APCS, Serum amyloid P-component, SAP, 9.5S alpha-1-glycoprotein