APEH

Function

This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:10719179, PubMed:1740429, PubMed:2006156). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins (PubMed:10719179).

Sequence Similarities

Belongs to the peptidase S9C family.

Tissue Specificity

Expressed in erythrocytes (at protein level).

Cellular localization

• Cytoplasm

Alternative names

D3F15S2, D3S48E, DNF15S2, APEH, Acylamino-acid-releasing enzyme, AARE, Acyl-peptide hydrolase, Acylaminoacyl-peptidase, Oxidized protein hydrolase, APH, OPH

Database links

swissprot:P13798 omim:102645 entrezGene:327 genbank:33875348