APOA1
Function
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Post-translational modifications
Glycosylated.
Palmitoylated.
Phosphorylation sites are present in the extracellular medium.
Sequence Similarities
Belongs to the apolipoprotein A1/A4/E family.
Tissue Specificity
Major protein of plasma HDL, also found in chylomicrons.
Cellular localization
- Secreted
Alternative names
Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1