Apoa1

Function

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

Post-translational modifications

Glycosylated.

Palmitoylated.

May be acylated.

Phosphorylation sites are present in the extracellular medium.

Sequence Similarities

Belongs to the apolipoprotein A1/A4/E family.

Tissue Specificity

Major protein of plasma HDL, also found in chylomicrons.

Cellular localization

• Secreted

Alternative names

Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1, Apoa1

Database links

swissprot:Q00623 entrezGene:11806

Other research areas

• Oncology