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Apolipoprotein A I
Function
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Post-translational modifications
Glycosylated.
Palmitoylated.
May be acylated.
Phosphorylation sites are present in the extracellular medium.
Sequence similarities
Belongs to the apolipoprotein A1/A4/E family.
Tissue specificity
Major protein of plasma HDL, also found in chylomicrons.
Cellular localization
- Secreted
Alternative names
- Apolipoprotein A-I
- Apo-AI
- ApoA-I
- Apolipoprotein A1
- Apoa1
Database links
Target type
Proteins
Primary research area
Cardiovascular
Other research areas
- Oncology
Molecular weight
30616Da