Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013).
Hyperalphalipoproteinemia 2
HALP2
A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.
None
The disease is caused by variants affecting the gene represented in this entry.
The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.
Belongs to the apolipoprotein C3 family.
Liver.
Proteins
10852Da
We found 13 products in 3 categories
ab245075
Anti-Apolipoprotein CIII antibody [EP1372-52] - BSA and Azide free (Detector)
ab244802
Anti-Apolipoprotein CIII antibody [EPR1371(2)] - BSA and Azide free (Capture)