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Apo-H

Function

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Post-translational modifications

N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele.

Tissue specificity

Expressed by the liver and secreted in plasma.

Cellular localization

  • Secreted

Alternative names

  • Beta-2-glycoprotein 1
  • APC inhibitor
  • Activated protein C-binding protein
  • Anticardiolipin cofactor
  • Apolipoprotein H
  • Beta-2-glycoprotein I
  • Apo-H
  • B2GPI
  • Beta(2)GPI
  • B2G1
  • APOH

Target type

Proteins

Molecular weight

38298Da