Apolipoprotein L1/APOL1

May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.

Focal segmental glomerulosclerosis 4

FSGS4

A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Phosphorylated by FAM20C in the extracellular medium.

Belongs to the apolipoprotein L family.

Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.

• Secreted

APOL, APOL1, Apolipoprotein L1, Apolipoprotein L, Apolipoprotein L-I, Apo-L, ApoL, ApoL-I

• entrezGene:8542
• omim:603743
• swissprot:O14791

Proteins

Metabolism

43974Da