APPBP2
Function
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29775578, PubMed:29779948). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29775578, PubMed:29779948). The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation (PubMed:29775578, PubMed:29779948). The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron (PubMed:26138980). May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface (PubMed:9843960).
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.
Cellular localization
- Nucleus
- Cytoplasm
- Cytoskeleton
- Membrane
- Peripheral membrane protein
- Associated with membranes and microtubules.
Alternative names
KIAA0228, PAT1, APPBP2, Amyloid protein-binding protein 2, Amyloid beta precursor protein-binding protein 2, Protein interacting with APP tail 1, APP-BP2