AQP12A
Domain
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Function
Putative aquaporin. Could form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient.
Sequence Similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
Tissue Specificity
Restricted to the pancreas.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
AQP12, AQPX2, AQP12A, Putative aquaporin-12A, AQP-12