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AQP6

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Function

Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.

Sequence Similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family.

Cellular localization

Alternative names

AQP2L, AQP6, Aquaporin-6, AQP-6, Aquaporin-2-like, Kidney-specific aquaporin, hKID

swissprot:Q13520 entrezGene:363 omim:601383