AQR
Domain
Contains an N-terminal domain with structural similarity to ARM repeat regions; this domain functions as a scaffold for protein-protein interactions, but is not required for RNA binding or for ATP-dependent RNA helicase activity.
Function
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28076346, PubMed:28502770). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396).
Sequence Similarities
Belongs to the CWF11 family.
Cellular localization
- Nucleus
- Nucleus
- Nucleoplasm
- Localizes to speckle-like regions of the nucleoplasm.
Alternative names
KIAA0560, AQR, RNA helicase aquarius, Intron-binding protein of 160 kDa, IBP160