Areg

Function

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

Sequence Similarities

Belongs to the amphiregulin family.

Cellular localization

• Membrane
• Single-pass membrane protein

Alternative names

Sdgf, Areg, Amphiregulin, AR, Schwannoma-derived growth factor, SDGF

Database links

swissprot:P31955 entrezGene:11839

Other research areas

• Immuno-oncology