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Amphiregulin

Function

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

Sequence similarities

Belongs to the amphiregulin family.

Cellular localization

  • Membrane
  • Single-pass membrane protein

Alternative names

Sdgf, Areg, Amphiregulin, AR, Schwannoma-derived growth factor, SDGF

Target type

Proteins

Primary research area

Oncology

Other research areas

  • Immuno-oncology

Molecular weight

27549Da