AREG

Function

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

Sequence Similarities

Belongs to the amphiregulin family.

Cellular localization

• Membrane
• Single-pass membrane protein

Alternative names

AREGB, SDGF, AREG, Amphiregulin, AR, Colorectum cell-derived growth factor, CRDGF

Database links

swissprot:P15514 omim:104640 entrezGene:374 entrezGene:727738

Other research areas

• Immuno-oncology