ARF4
Function
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879).
Sequence Similarities
Belongs to the small GTPase superfamily. Arf family.
Cellular localization
- Golgi apparatus
- Membrane
- Lipid-anchor
Alternative names
ARF2, ARF4, ADP-ribosylation factor 4