ARHGEF11
Domain
The poly-Pro region is essential for plasma membrane localization upon stimulation.
Function
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
Post-translational modifications
Phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14).
Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex when previously phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14), leading to its degradation, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Cytoplasm
- Membrane
- Translocated to the membrane upon stimulation.
Alternative names
KIAA0380, ARHGEF11, Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF