ARHGEF16

The PDZ-binding motif mediates interaction with TAX1BP3.

Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.

• Cytoplasm

EPHEXIN4, NBR, ARHGEF16, Rho guanine nucleotide exchange factor 16, Ephexin-4

• entrezGene:27237
• swissprot:Q5VV41

Proteins

Oncology

80105Da