ARHGEF7
Function
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Post-translational modifications
Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1.
Cellular localization
- Cell junction
- Focal adhesion
- Cell projection
- Ruffle
- Cytoplasm
- Cell cortex
- Cell projection
- Lamellipodium
- Detected at cell adhesions. A small proportion is detected at focal adhesions.
Alternative names
COOL1, KIAA0142, P85SPR, PAK3BP, PIXB, Nbla10314, ARHGEF7, Rho guanine nucleotide exchange factor 7, Beta-Pix, COOL-1, PAK-interacting exchange factor beta, p85