ARK2N
Function
AMPK substrate important for exercise capacity and skeletal muscle function. Required for normal contraction-induced signaling.
(Microbial infection) Upon Epstein-Barr virus (EBV) infection, suppresses viral BZLF1 expression and subsequent EBV reactivation by interacting with JUN and inhibiting its transcriptional activitor activity on BZLF1 Z promoter.
Post-translational modifications
Phosphorylated at Ser-67 by AMPK. In skeletal muscle, phosphorylation is induced by exercise and seems to increase muscle contractile function.
Tissue Specificity
Expressed in skeletal muscle.
Cellular localization
- Nucleus
Alternative names
ARKL1, C18orf25, ARK2N, Protein ARK2N, ARKadia-like protein 1, Arkadia (RNF111) N-terminal like PKA signaling regulator protein 2N