ARL4A
Function
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.
Post-translational modifications
Myristoylated.
Sequence Similarities
Belongs to the small GTPase superfamily. Arf family.
Cellular localization
- Cell membrane
- Cytoplasm
- Nucleus
- Nucleolus
- Localization in the nucleolus is dependent by nucleotide binding.
Alternative names
ARL4, ARL4A, ADP-ribosylation factor-like protein 4A