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ARL4A

OverviewProducts

Function

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Post-translational modifications

Myristoylated.

Sequence similarities

Belongs to the small GTPase superfamily. Arf family.

Cellular localization

  • Cell membrane
  • Cytoplasm
  • Nucleus
  • Nucleolus
  • Localization in the nucleolus is dependent by nucleotide binding.

Alternative names

  • ADP-ribosylation factor-like protein 4A
  • ARL4A
  • ARL4

Database links

Target type

Proteins

Molecular weight

22615Da