ARL4C

Function

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.

Sequence Similarities

Belongs to the small GTPase superfamily. Arf family.

Tissue Specificity

Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta.

Cellular localization

• Cell projection
• Filopodium
• Cell membrane
• Cytoplasm

Alternative names

ARL7, ARL4C, ADP-ribosylation factor-like protein 4C, ADP-ribosylation factor-like protein 7, ADP-ribosylation factor-like protein LAK

Database links

swissprot:P56559 entrezGene:10123 genbank:NP_005728 omim:604787