ARL6IP5
Function
Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum.
Sequence Similarities
Belongs to the PRA1 family.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Cell membrane
- Multi-pass membrane protein
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Also exists as a soluble form in the cytoplasm. Associated with microtubules.
Alternative names
DERP11, JWA, PRA2, PRAF3, HSPC127, ARL6IP5, PRA1 family protein 3, ADP-ribosylation factor-like protein 6-interacting protein 5, Cytoskeleton-related vitamin A-responsive protein, Dermal papilla-derived protein 11, GTRAP3-18, Glutamate transporter EAAC1-interacting protein, JM5, Prenylated Rab acceptor protein 2, Protein JWa, Putative MAPK-activating protein PM27, ARL-6-interacting protein 5, Aip-5