ARL6IP5

Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum.

Belongs to the PRA1 family.

• Endoplasmic reticulum membrane
• Multi-pass membrane protein
• Cell membrane
• Multi-pass membrane protein
• Cytoplasm
• Cytoplasm
• Cytoskeleton
• Also exists as a soluble form in the cytoplasm. Associated with microtubules.

DERP11, JWA, PRA2, PRAF3, HSPC127, ARL6IP5, PRA1 family protein 3, ADP-ribosylation factor-like protein 6-interacting protein 5, Cytoskeleton-related vitamin A-responsive protein, Dermal papilla-derived protein 11, GTRAP3-18, Glutamate transporter EAAC1-interacting protein, JM5, Prenylated Rab acceptor protein 2, Protein JWa, Putative MAPK-activating protein PM27, ARL-6-interacting protein 5, Aip-5

• entrezGene:10550
• omim:605709
• swissprot:O75915

Proteins

21615Da