ARL8A

Function

Plays a role in lysosome motility (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity).

Sequence Similarities

Belongs to the small GTPase superfamily. Arf family.

Tissue Specificity

Ubiquitously expressed.

Cellular localization

• Late endosome membrane
• Lysosome membrane
• Cytoplasm
• Cytoskeleton
• Spindle
• Cell projection
• Axon
• Synapse
• Localizes with microtubules at the spindle mid-zone during mitosis.

Alternative names

ARL10B, GIE2, ARL8A, ADP-ribosylation factor-like protein 8A, ADP-ribosylation factor-like protein 10B, Novel small G protein indispensable for equal chromosome segregation 2

Database links

swissprot:Q96BM9 entrezGene:127829 entrezGene:55207 swissprot:Q9NVJ2