Essential for male fertility and sperm motility (By similarity). During spermatogenesis, promotes the autophagic degradation of excessive ribosomes, providing energy resources for mitochondria and thus ensuring sperm flagellar motility (PubMed:34428398).
Palmitoylation is important for its function in autophagy.
Isoform 1
Expressed in skeletal muscle, brain, lung, kidney, prostate and testis.
Isoform 3
Mainly expressed in skeletal muscle, liver, spleen and thymus.
Isoform 5
Expressed only in the testis among normal tissues but is expressed frequently in various cancer tissues and, particularly, in pancreatic, lung and endometrial cancers.
Armadillo repeat-containing protein 3, Beta-catenin-like protein, Cancer/testis antigen 81, KU-CT-1, CT81, ARMC3
Proteins
96405Da
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