HIF1 beta

Function

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).

Cellular localization

• Nucleus

Alternative names

• Aryl hydrocarbon receptor nuclear translocator
• ARNT protein
• Class E basic helix-loop-helix protein 2
• Hypoxia-inducible factor 1-beta
• bHLHe2
• HIF-1-beta
• HIF1-beta
• BHLHE2
• ARNT

Database links

• entrezGene:405
• omim:126110
• swissprot:P27540

Target type

Proteins

Primary research area

Epigenetics

Other research areas

• Oncology

Molecular weight

86636Da