ARPIN
Domain
The acidic C-terminus is necessary and sufficient to inhibit ARP2/3 complex activity.
Function
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
Sequence Similarities
Belongs to the Arpin family.
Cellular localization
- Cell projection
- Lamellipodium
- Colocalized with the WAVE complex at lamelliupodium tip.
Alternative names
C15orf38, ARPIN, Arpin, Arp2/3 inhibition protein