ARRDC4
Function
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake (PubMed:19605364). Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 (PubMed:28594402).
Sequence Similarities
Belongs to the arrestin family.
Cellular localization
- Early endosome
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- Cytoplasmic vesicle
- Also found in extracellular vesicles different from exosomes.
Alternative names
Arrestin domain-containing protein 4, ARRDC4