ASAP2
Domain
The conserved Arg-464 in the Arf-GAP domain probably becomes part of the active site of bound small GTPases and is necessary for GTP hydrolysis.
Function
Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration.
Post-translational modifications
Phosphorylated on tyrosine residues by SRC and PTK2B.
Tissue Specificity
Detected in heart, brain, placenta, kidney, monocytes and pancreas.
Cellular localization
- Cytoplasm
- Golgi apparatus
- Golgi stack membrane
- Peripheral membrane protein
- Cell membrane
- Peripheral membrane protein
- Colocalizes with F-actin and ARF6 in phagocytic cups.
Alternative names
DDEF2, KIAA0400, ASAP2, Development and differentiation-enhancing factor 2, Paxillin-associated protein with ARF GAP activity 3, Pyk2 C-terminus-associated protein, PAG3, PAP