ASB8
Domain
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Function
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the ankyrin SOCS box (ASB) family.
Tissue Specificity
Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas.
Cellular localization
- Cytoplasm
Alternative names
PP14212, ASB8, Ankyrin repeat and SOCS box protein 8, ASB-8