ASB9
Function
Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:25654263, PubMed:33268465). The ECS(ASB9) complex catalyzes ubiquitination of creatine kinases CKB and CKMT1A (PubMed:20302626, PubMed:22418839, PubMed:25654263, PubMed:33268465).
Isoform 2
Does not interact with the Elongin BC complex, likely to be a negative regulator of isoform 1.
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the ankyrin SOCS box (ASB) family.
Tissue Specificity
Predominantly expressed in testis, kidney, and liver.
Cellular localization
- Mitochondrion
Alternative names
Ankyrin repeat and SOCS box protein 9, ASB-9, ASB9