ASCL3
Function
Transcriptional repressor. Inhibits myogenesis. Plays a role in progenitor cells which differentiate into ductal and acinar, but not myoepithelial, cell lineages in the salivary glands. Involved in the functions of the microvillar cells and Bowman's glands and probably, in a non-cell-autonomous manner, in the development or regeneration of a complete olfactory epithelium (OE).
Tissue Specificity
Widely expressed in fetal and adult tissues.
Cellular localization
- Nucleus
Alternative names
BHLHA42, HASH3, SGN1, ASCL3, Achaete-scute homolog 3, ASH-3, hASH3, Class A basic helix-loop-helix protein 42, bHLH transcriptional regulator Sgn-1, bHLHa42