ASF1

Highly expressed in embryos and at lower levels in larvae, pupae and adults.

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10591219, PubMed:12381660, PubMed:14561777, PubMed:16151251, PubMed:16396992). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11533245). Plays a role in the formation of silent heterochromatin (PubMed:12381660, PubMed:28320872).

Phosphorylated on undefined residues by tlk.

Belongs to the ASF1 family.

• Nucleus
• Chromosome
• Localizes to multiple sites on polytene chromosomes including transcriptionally active developmental puffs, the chromocenter and the histone gene cluster (PubMed:12381660). Localizes to active foci of DNA replication throughout S-phase and is lost from stalled replication forks (PubMed:16396992). Not detected on condensed chromatin during mitosis (PubMed:16396992).

CG9383, asf1, Histone chaperone asf1, Anti-silencing function protein 1, Replication-coupling assembly factor subunit ASF1, dASF1, RCAF subunit ASF1

• swissprot:Q9V464

Proteins