ASGR1
Function
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Post-translational modifications
Phosphorylated on a cytoplasmic Ser residue.
Tissue Specificity
Expressed exclusively in hepatic parenchymal cells.
Cellular localization
- Isoform H1a
- Membrane
- Single-pass type II membrane protein
- Isoform H1b
- Secreted
Alternative names
CLEC4H1, ASGR1, Asialoglycoprotein receptor 1, ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1