ASIC2
Function
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Sequence Similarities
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily.
Tissue Specificity
Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.
Alternative names
ACCN, ACCN1, BNAC1, MDEG, ASIC2, Acid-sensing ion channel 2, Amiloride-sensitive brain sodium channel, Amiloride-sensitive cation channel neuronal 1, Brain sodium channel 1, Mammalian degenerin homolog, BNC1, BNaC1