ASIC3
Developmental stage
Expressed in fetal tissues, expression increases in lung and kidney adult tissues.
Domain
The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1.
Function
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
Post-translational modifications
Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ASIC3/ACCN3-ASIC2/ASIC2b channel, but does not activate a homomeric ASIC3 channel (By similarity).
Sequence Similarities
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily.
Tissue Specificity
Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cytoplasm
- Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity).
Alternative names
ACCN3, SLNAC1, TNAC1, ASIC3, Acid-sensing ion channel 3, hASIC3, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Testis sodium channel 1, hTNaC1