Tether containing UBX domain for GLUT4

Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.

A chromosomal aberration involving ASPSCR1 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with TFE3 forms a ASPSCR1-TFE3 fusion protein.

A chromosomal aberration involving ASPSCR1 has been found in two patients with of papillary renal cell carcinoma. Translocation t(X;17)(p11.2;q25).

Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas.

• Endomembrane system
• Peripheral membrane protein
• Endoplasmic reticulum-Golgi intermediate compartment membrane
• Peripheral membrane protein
• Cytoplasm
• Nucleus

ASPL, RCC17, TUG, UBXD9, UBXN9, ASPSCR1, Tether containing UBX domain for GLUT4, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, Renal papillary cell carcinoma protein 17, UBX domain-containing protein 9

• entrezGene:79058
• omim:606236
• swissprot:Q9BZE9

Proteins

Neuroscience

60183Da