ASTN1
Function
Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development.
Sequence Similarities
Belongs to the astrotactin family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Perikaryon
- Endosome
- Cytoplasmic vesicle
- Clathrin-coated vesicle
- Detected close to the anterior pole and at the base of the leading process in migrating neurons. Is internalized from the membrane via clathrin-coated vesicles and endosomes, and recycled to the anterior pole of the migrating cell.
Alternative names
ASTN, KIAA0289, ASTN1, Astrotactin-1