ATAD3B
Developmental stage
Expressed in proliferating embryonic stem cells and down-regulated during differentiation.
Function
May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. May act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.
Sequence Similarities
Belongs to the AAA ATPase family.
Tissue Specificity
Tends to be down-regulated in differentiated cells and re-expressed in pluripotent stem cells or cancer cells (at protein level).
Cellular localization
- Mitochondrion inner membrane
- Peripheral membrane protein
- Has been found to co-purify with nucleoids (PubMed:22453275). Since it does not face the mitochondrial matrix, the association with nucleoids could be mediated by ATAD3A.
Alternative names
KIAA1273, TOB3, ATAD3B, ATPase family AAA domain-containing protein 3B, AAA-TOB3