ATF7IP2
Function
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable).
Sequence Similarities
Belongs to the MCAF family.
Cellular localization
- Nucleus
Alternative names
MCAF2, ATF7IP2, Activating transcription factor 7-interacting protein 2, ATF7-interacting protein 2, MBD1-containing chromatin-associated factor 2