ATG10
Function
E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.
Sequence Similarities
Belongs to the ATG10 family.
Cellular localization
- Cytoplasm
Alternative names
APG10L, PP12616, ATG10, Ubiquitin-like-conjugating enzyme ATG10, Autophagy-related protein 10, APG10-like