ATG2B
Domain
The chorein N-terminal domain mediates lipid transfer activity.
Function
Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365).
Sequence Similarities
Belongs to the ATG2 family.
Cellular localization
- Preautophagosomal structure membrane
- Peripheral membrane protein
- Lipid droplet
- Endoplasmic reticulum membrane
- Peripheral membrane protein
Alternative names
C14orf103, ATG2B, Autophagy-related protein 2 homolog B