Skip to main content

ATG4B

Function

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Sequence similarities

Belongs to the peptidase C54 family.

Cellular localization

  • Cytoplasm

Alternative names

  • Cysteine protease ATG4B
  • AUT-like 1 cysteine endopeptidase
  • Autophagin-1
  • Autophagy-related cysteine endopeptidase 1
  • Autophagy-related protein 4 homolog B
  • hAPG4B
  • APG4B
  • KIAA0943
  • AUTL1
  • ATG4B

Target type

Proteins

Molecular weight

44294Da