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ATG4C

Function

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Sequence similarities

Belongs to the peptidase C54 family.

Cellular localization

  • Cytoplasm

Alternative names

  • Cysteine protease ATG4C
  • AUT-like 3 cysteine endopeptidase
  • Autophagin-3
  • Autophagy-related cysteine endopeptidase 3
  • Autophagy-related protein 4 homolog C
  • AUTL1
  • AUTL3
  • APG4C
  • ATG4C

Target type

Proteins

Molecular weight

52497Da