ATG7

Developmental stage

Up-regulated during leaf senescence.

Domain

The C-terminal residues are required for homodimerization, as well as the interactions with ATG3, ATG8 and ATG12.

The GxGxxG motif is important for the function, possibly through binding with ATP.

Function

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process (PubMed:12070171). Involved in the degradation of damaged peroxisomes (PubMed:24368788). Involved in the non-selective degradation of chlorophylls and photosynthetic proteins during stress-induced leaf yellowing (PubMed:24510943).

Sequence Similarities

Belongs to the ATG7 family.

Tissue Specificity

Constitutively expressed (at protein level).

Alternative names

APG7, PEUP4, At5g45900, K15I22.10, ATG7, Ubiquitin-like modifier-activating enzyme atg7, ATG12-activating enzyme E1 atg7, Autophagy-related protein 7, Protein PEROXISOME UNUSUAL POSITIONING 4, AtAPG7

Database links

swissprot:Q94CD5 entrezGene:834630

Other research areas

• Neuroscience