ATMIN
Function
Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.
Tissue Specificity
Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle.
Cellular localization
- Nucleus
- Nuclear, in discrete foci during G1 phase.
Alternative names
KIAA0431, ZNF822, ATMIN, ATM interactor, ATM/ATR-substrate CHK2-interacting zinc finger protein, Zinc finger protein 822, ASCIZ