ATOX1

The heavy-metal-associated domain (HMA) coordinates a Cu(+) ion via the cysteine residues within the CXXC motif. The transfer of Cu(+) ion from ATOX1 to ATP7A involves the formation of a three-coordinate Cu(+)-bridged heterodimer where the metal is shared between the two metal binding sites of ATOX1 and ATP7A. The Cu(+) ion appears to switch between two coordination modes, forming two links with one protein and one with the other. Cisplatin, a chemotherapeutic drug, can bind the CXXC motif and hinder the release of Cu(+) ion.

Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.

Belongs to the ATX1 family.

Ubiquitous.

HAH1, ATOX1, Copper transport protein ATOX1, Metal transport protein ATX1

• entrezGene:475
• omim:602270
• swissprot:O00244

Proteins

Neuroscience

7402Da