ATP11B
Function
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401).
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Cellular localization
- Recycling endosome membrane
- Multi-pass membrane protein
- Early endosome
- Endoplasmic reticulum
- Golgi apparatus
- trans-Golgi network
- Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:21914794). In the presence of TMEM30A, mainly located in recycling endosomes (PubMed:21914794).
Alternative names
ATPIF, ATPIR, KIAA0956, ATP11B, Phospholipid-transporting ATPase IF, ATPase IR, ATPase class VI type 11B, P4-ATPase flippase complex alpha subunit ATP11B