Atp6ap2

Developmental stage

Expressed at 12 dpc throughout the developing cortex with notable apical enrichment in radial glial cells (RGCs) along the ventricular surface.

Function

Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system (By similarity). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (By similarity). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (PubMed:26376863, PubMed:29127204, PubMed:30985297).

Post-translational modifications

Phosphorylated.

Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments.

Tissue Specificity

Expressed in glutamatergic and GABAergic neurons with highest levels in the cortex, the hippocampus, the medial habenular nucleus, the cerebellum, the medulla and the olfactory bulb (at protein level).

Cellular localization

• Endoplasmic reticulum membrane
• Single-pass type I membrane protein
• Lysosome membrane
• Single-pass type I membrane protein
• Cytoplasmic vesicle
• Autophagosome membrane
• Single-pass type I membrane protein
• Cell projection
• Dendritic spine membrane
• Single-pass type I membrane protein
• Cell projection
• Axon
• Endosome membrane
• Single-pass type I membrane protein
• Cytoplasmic vesicle
• Clathrin-coated vesicle membrane
• Single-pass type I membrane protein
• Cytoplasmic vesicle
• Secretory vesicle
• Synaptic vesicle membrane
• Single-pass type I membrane protein

Alternative names

Atp6ip2, Atp6ap2, Renin receptor, ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H(+)-transporting lysosomal-interacting protein 2, Renin/prorenin receptor

Database links

swissprot:Q9CYN9