ATRIP phospho S68
Domain
The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.
Function
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
Post-translational modifications
Phosphorylated by ATR.
Sequence Similarities
Belongs to the ATRIP family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Nucleus
- Redistributes to discrete nuclear foci upon DNA damage.
Alternative names
AGS1, ATRIP, ATR-interacting protein, ATM and Rad3-related-interacting protein