ATXN2L

Involved in the regulation of stress granule and P-body formation.

Thrombopoietin triggers the phosphorylation on tyrosine residues in a way that is dependent on MPL C-terminal domain.

Asymmetrically dimethylated. Probably methylated by PRMT1.

Belongs to the ataxin-2 family.

Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.

• Membrane
• Peripheral membrane protein
• Cytoplasm
• Nucleus speckle
• Cytoplasmic granule
• Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791). Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791).

A2D, A2LG, A2LP, A2RP, ATXN2L, Ataxin-2-like protein, Ataxin-2 domain protein, Ataxin-2-related protein

• entrezGene:11273
• omim:607931
• swissprot:Q8WWM7

Proteins

113374Da