ATXN2L
Function
Involved in the regulation of stress granule and P-body formation.
Post-translational modifications
Thrombopoietin triggers the phosphorylation on tyrosine residues in a way that is dependent on MPL C-terminal domain.
Asymmetrically dimethylated. Probably methylated by PRMT1.
Sequence Similarities
Belongs to the ataxin-2 family.
Tissue Specificity
Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.
Cellular localization
- Membrane
- Peripheral membrane protein
- Cytoplasm
- Nucleus speckle
- Cytoplasmic granule
- Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791). Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791).
Alternative names
A2D, A2LG, A2LP, A2RP, ATXN2L, Ataxin-2-like protein, Ataxin-2 domain protein, Ataxin-2-related protein